HIGH NORMAL THYROID-STIMULATING HORMONE IS ASSOCIATED WITH ARTERIAL STIFFNESS, CENTRAL SYSTOLIC BLOOD PRESSRUE, AND 24-HOUR SYSTOLIC BLOOD PRESSURE IN MALE WITH TREATMENT-NAÏVE HYPERTENDSION AND EUTHYROID

Abstract

s S211 305 HIGH NORMAL THYROID-STIMULATING HORMONE IS ASSOCIATED WITH ARTERIAL STIFFNESS, CENTRAL SYSTOLIC BLOOD PRESSRUE, AND 24-HOUR SYSTOLIC BLOOD PRESSURE IN MALE WITH TREATMENT-NAIVE HYPERTENDSION AND EUTHYROID B Kwon, J Roh, H Kim, S Ihm Seogwipo, Korea, Republic of BACKGROUND: The data addressing the association serum thyroid-stimulating hormone (TSH) levels within the reference range and blood pressure (BP) are so far inconsistent in patients with euthyroid. Therefore, we tried to investigate whether differ in various BP parameters between the patients with low normal TSH and high normal TSH levels. METHODS: The prospective study groups consisted of consecutive 285 patients with treatment-naive hypertension and euthryoid undergoing comprehensive laboratory examinations, transthoracic echocardiography (TTE), brachial-ankle pulse wave velocity (PWV), ankle-brachial index, central BPs, and 24-hour ambulatory BP monitoring (ABPM) evaluations. All patients with normal TSH (0.40w4.50 mIU/ml) and free thyroxine levels (0.60w1.90 ng/dl) were divided into those with low normal TSH (0.40w1.99 mIU/ml, group 1) and those with high-normal TSH (2.00-4.50 mIU/ml, group 2) and compared according to group and gender. RESULTS: Treatment-naive hypertensive male patients were divided into group 1 (n1⁄4113, 68.9%) and group 2 (n1⁄451, 31.1%) and female patients were divided into group 1 (n1⁄471, 58.7%) and group 2 (n1⁄450, 41.3%). Multivariate analyses revealed that augmentation index (AIx, 71.0 [adjusted mean] 1.7 [standard error] vs. 78.8 2.5 %, p1⁄40.045), central systolic BP (SBP) (143.3 2.1 vs. 153.0 3.2 mmHg, p1⁄40.013), systemic vascular resistance (21.4 0.6 vs. 23.9 0.9 mmHg/L/min, p1⁄40.027), and SBP in daytime (144.1 1.4 vs. 151.6 2.1 mmHg, p1⁄40.004) and nighttime (130.4 1.6 vs. 138.5 2.5 mmHg, p1⁄40.008), and nighttime PP (47.2 0.9 vs. 51.7 1.4 mmHg, p1⁄40.010) were significantly higher and cardiac output (5.4 0.1 vs. 4.8 0.2 L/ min, p1⁄40.043) and pulse pressure (PP) amplification (1.02 0.02 vs. 0.94 0.03, p1⁄40.039) were significantly lower in a group 2 of male patients. After multivariate analyses, SBP (b1⁄40.225, p1⁄40.010) and PP (b1⁄40.179, p1⁄40.022) at office, PWV (high value) (b1⁄40.192, p1⁄40.036), AIx (b1⁄40.285, p1⁄40.007), central SBP (b1⁄40.351, p1⁄40.001), DBP (b1⁄40.246, p1⁄40.012), and PP (b1⁄40.317, p1⁄40.006), SBP in daytime (b1⁄40.219, p1⁄40.004) and nighttime (b1⁄40.232, p1⁄40.013), and PP in 24-hour (b1⁄40.216, p1⁄40.005) and nighttime (b1⁄40.172, p1⁄40.024) were linearly associated with levels of TSH in hypertensive male. CONCLUSION: Despite euthryoid, arterial stiffness, central SBP, and SBP in ABPM are higher and cardiac output and PP amplification are lower in high normal TSH group among treatment-naive hypertensive male, but not female. Arterial stiffness, SBP and PP at office, central BPs, and SBP and PP in ABPM are linearly associated with levels of TSH among hypertensive male. 306 MMP-2 MEDIATES A MECHANISM OF METABOLIC CARDIOPROTECTION CONSISTING OF NEGATIVE REGULATION OF THE SREBP/HMGCR/ADAM-12 PATHWAY IN THE HEART C Fernandez-Patron, X Wang, Z Kassiri, S Hernandez-Anzaldo, E Berry, D Zhang, L Li