Abstract
Lysine-rich (H1) histones were isolated from mammary tumors of GR mice. Chromatography of the H1 histone class on a long column (130 X 1 cm) of Amberlite IRC-50 resin revealed the presence of nine components, designated 1-9 according to their order of elution. Amino acid analysis indicated that components 2-9 represented H1 class histones, but that peak 1 represented a nonhistone protein. Studies of three types of mouse mammary tumors, viz. hormone-dependent, hormone-responsive and hormone-independent, did not reveal significant differences in elution profiles of the H1 histones. In contrast, the H1 histone class from a dog mammary tumor differed chromatographically from that of mouse mammary tumors, indicating species specificity in elution patterns of mammary tumor H1 histones.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
