Abstract
Hyaluronan (HA) is a linear polysaccharide has a high-molecular weight, naturally occurring and found in all tissues and body fluids of higher animals. The excellent properties of HA such as biodegradability, biocompatibility, safety, excellent mucoadhesive capacity and high water retaining ability make it well-qualified for using in various bio-medical applications. In addition, HA is non-toxic, non-inflammatory and non-immunogenic. Because of all these advantages, HA has received much attention as a matrix for drug delivery system. This review will summarize our present knowledge about HA, its properties and development in some pharmaceutical applications.
Highlights
Bottner and his co-workers have proved that that thermal degradation of HA occurs in agreement with the random-scission mechanism during the study of two high-molar-mass HA samples that were extensively degraded at 128 °C in an autoclave
The results showed that the release of gentamicin is prolonged when formulated in HA, CH and HA/ CH and that the resultant microparticles are mucoadhesive in nature
The results proved that HA, a non-toxic biomolecule used as a excellent mucoadhesive polymer in a nasal formulation, increased the brain penetration of a hydrophilic compound, the size of a peptide, via the nasal route
Summary
High-Molecular Weight Biopolymer not fully completed when using different HA samples under applying different ultrasound energies, and the increasing of absorbance at 232 nm after sonication is not observed Heat is another type of the physical methods used for HA degradation, in which with increasing temperature the degradation increased and the viscosity strongly decreased. In case of thermal degradation method, it was reported that the treatment of different HA samples at temperatures from 60 to 90 °C for 1 h results in only moderate degradation and a small increase of polydispersity Bottner and his co-workers have proved that that thermal degradation of HA occurs in agreement with the random-scission mechanism during the study of two high-molar-mass HA samples that were extensively degraded at 128 °C in an autoclave. Soltes and his team focused their research on the hydroxyl radicals resulting from the reaction
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