Abstract
INTRODUCTION HIGH MOLECULAR weight glycoproteins, often described as mucins or mucin-like components, are frequently found associated with human breast carcinomas. These components are highly immunogenic and they have been identified as the target antigens for many monoclonal antibodies raised against human milk fat globule membranes or breast carcinoma cells. Such mucin antigens are clearly the products of normal epithelia as well as their malignant counterparts. Even so, despite this lack of tumor specificity, there is an increasing appreciation that epithelial mucins may be usefully exploited in both basic and clinical studies in breast cancer.
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