Abstract
BackgroundSerum adiponectin levels are associated with frailty and cardiovascular diseases. Longitudinal changes in adiponectin levels might enhance our understanding of age-related conditions and diseases.AimsThis prospective observational study aimed to: (1) elucidate age-related changes in high-molecular-weight (HMW) adiponectin levels; and (2) identify variables predictive of elevated HMW adiponectin levels and the association with well-known adiponectin single-nucleotide polymorphisms (SNPs) in healthy, elderly Japanese participants.MethodsHealthy elderly volunteers (n = 196; 55 men and 141 women; median age 72.0 years; range 69.0–75.0 years) underwent anthropometric and physical function measurements, as well as laboratory tests at baseline and the 5-year follow-up.ResultsHMW adiponectin levels were significantly higher in women than in men (8.4, 5.3–11.9 vs. 5.7, 3.1–9.0 μg/mL; p < 0.001) at baseline and decreased significantly at follow-up in women (7.7, 4.8–11.2 μg/mL; p < 0.001), but not in men. In the multiple regression analysis, high-density lipoprotein cholesterol levels and body weight were independent predictors of HMW adiponectin levels. The rate of change in HMW adiponectin levels was inversely correlated with the rates of change in body weight, body mass index, and knee leg extension strengths, and positively correlated with rates of change in high-density lipoprotein cholesterol and one-leg standing time. There were no significant differences in HMW adiponectin levels among SNPs.DiscussionDecreasing HMW adiponectin levels might lead to an increased risk of cardiovascular diseases in elderly women.ConclusionHMW adiponectin levels significantly decreased over a 5-year period in community-dwelling elderly Japanese women.
Highlights
Adiponectin is an adipose tissue-derived specific protein encoded by the adiponectin gene (ADIPOQ) located on chromosome 3q27 in a region identified as a susceptibility locus for metabolic syndrome [1]
Serum levels of adiponectin have been associated with glucose intolerance, diabetes mellitus, and cardiovascular diseases (CVD) [2, 3]
We identified variables predictive of elevated HMW adiponectin levels and investigated the association between plasma HMW adiponectin levels and single-nucleotide polymorphisms (SNPs) in ADIPOQ
Summary
Adiponectin is an adipose tissue-derived specific protein encoded by the adiponectin gene (ADIPOQ) located on chromosome 3q27 in a region identified as a susceptibility locus for metabolic syndrome [1]. In a recent analysis of older Korean adults, age was associated with total adiponectin levels in males but not females [8], suggesting the sex-associated differences. According to these reports, age and sex should be considered in the evaluation of plasma adiponectin levels. Longitudinal changes in adiponectin levels may be useful to understand healthy aging and agerelated diseases and/or conditions. Aims This prospective observational study aimed to: (1) elucidate age-related changes in high-molecular-weight (HMW) adiponectin levels; and (2) identify variables predictive of elevated HMW adiponectin levels and the association with well-known adiponectin single-nucleotide polymorphisms (SNPs) in healthy, elderly Japanese participants. Conclusion HMW adiponectin levels significantly decreased over a 5-year period in community-dwelling elderly Japanese women
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