Abstract
Objective: To investigate the expression of High Mobility Group Box 1 (HMGB1) and Heat Shock Protein-70 (HSP-70) during orthodontic tooth movement (OTM) after (-)- Epigallocatechin-3-Gallate (EGCG) in East Java Green Tea (Camelia Sinensis) Methanolic Extract (GTME) administration in vivo. Material and Methods: 28 Wistar rats (Rattus Novergicus) was used and divided into 4 groups accordingly: K- without EGCG and OTM; K+ with OTM, without EGCG for 14 days; T1with OTM for 14 days and EGCG for 7 days; treatment group 2 (T2) with OTM and EGCG for 14 days. OTM animal model was achieved through the installation of the OTM device by means of NiTi close coil spring with 10g force placed between the first incisor and first maxillary molars. The samples were terminated on Day 14. The pre-maxillary was isolated for the immunohistochemical examination. Analysis of Variance (ANOVA) then continued with Tukey Honest Significant Difference (HSD) (p<0.05) was performed to analyze the data. Results: The highest HMGB1 and HSP-70 expression were found in the K+ group pressure side, meanwhile the lowest HMGB1 and HSP-70 expression were found in K- group tension side in the alveolar bone. There was a significant decrease of HMGB1 and HSP-70 expression in T2 compared to T1 and K+ with significant between groups (p<0.05; p=0.0001). Conclusion: The decreased expression of HMGB1 and HSP-70 in alveolar bone of OTM wistar rats due to post administration of GTME that consisted EGCG.
Highlights
In the modern economic era, tea is an important economic commodity and it has abundant benefits for the human being
There was a significant decrease of High Mobility Group Box 1 (HMGB1) and Heat Shock Protein-70 (HSP-70) expression in treatment group 2 (T2) compared to T1 and K+ with significant between groups (p
There was a significant decrease of HMGB1 expression between groups (p=0.0001) (Figure 2 C-D)
Summary
In the modern economic era, tea is an important economic commodity and it has abundant benefits for the human being. In countries like China, United Kingdom, Japan and Indonesia, drinking tea has become a culture. The number of tea consumption and production increase annually in the world. Tea production has been increased from 3.152.987 in 2003 to 3.233.216 tons in 2004, while consumption from 1.344.200 in 2003 to 1.414.400 tons in 2004. The largest tea producer in the world is India, China, Sri Lanka, Kenya and Indonesia, with about 65% export of tea products. Indonesia is a tropical country with a good climate for tea plant to grow. One of tea field in Indonesia located in Perusahaan Perkebunan Nusantara XII, Wonosari, Lawang, Malang, East Java, Indonesia [1]
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