Abstract
BackgroundManganese (Mn) participates in lipid metabolism. However, the associations between Mn exposure and dyslipidaemia is unclear.MethodsThis was a cross-sectional study. Data were collected from the 2017 the Mn-exposed workers healthy cohort (MEWHC). Finally, 803 occupationally Mn-exposed workers included in the study. The workers were divided into two groups. The grouping of this study was based on Mn-Time Weighted Averages (Mn-TWA). The high-exposure group included participants with Mn-TWA greater than 0.15 mg/m3. The low-exposure group included participants with Mn-TWA less than or equal to 0.15 mg/m3. Mn-TWA levels and dyslipidaemia were assessed.ResultsAfter adjustment for seniority, sex, cigarette consumption, alcohol consumption, high-fat diet frequency, medicine intake in the past two weeks, egg intake frequency, drinking tea, WHR, and hypertension, Mn-TWA levels was negatively correlated with high triglycerides (TG) risk in workers overall (OR = 0.51; 95% CI: 0.36, 0.73; p < 0.01). The results of males and females were consistent (OR = 0.53; 95% CI: 0.34, 0.81; p < 0.01) and (OR = 0.47; 95% CI: 0.24, 0.94; p < 0.01), respectively. By performing interactions analyses of workers overall, we observed no significant interactions among confounders. Mn-TWA levels and pack-years on high TG risk (relative excess risk for the interactions (RERI = 2.29, 95% CI: − 2.07, 6.66), (RERI) = 2.98, 95% CI: − 2.30, 8.26). Similarly, smoking status, drinking status, high-fat diet frequency, and Waist-to-Hip Ratio (WHR) showed non-significant interactions with Mn-TWA levels on high TG risk.ConclusionsThis research indicates that high Mn exposure was negatively related to high TG risk in workers.
Highlights
IntroductionThe associations between Mn exposure and dyslipidaemia is unclear
Mn is vital for human health and is reflected in physiological metabolism [1,2,3]
Adjusted for potential confounding factors as sex, seniority, Waist-to-Hip Ratio (WHR), high blood pressure, drug intake in the past half month, high-fat diet consumption, egg intake frequency, drinking tea, smoking and drinking status, high TG risk significantly decreased in high exposure group (OR = 0.66; 95% CI: 0.48, 0.92; p < 0.01), and consistent negative correlation was found in males (OR = 0.53; 95% CI: 0.34, 0.81; p < 0.01) and females (OR = 0.47; 95% CI: 0.24, 0.94; p < 0.01)
Summary
The associations between Mn exposure and dyslipidaemia is unclear. Mn is vital for human health and is reflected in physiological metabolism [1,2,3]. Occupational overexposure to Mn exerts neurotoxic effects [4,5,6,7]. Mn reduces the total antioxidant status of rats and increases brain lipid peroxidation [8, 9]. An important synthesis pathway for many lipids in the mevalonate pathway, with mevalonate being the first branch in this pathway [12,13,14,15]
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