Abstract
Aim: Subjects with familial hypercholesterolemia (FH) are characterized by increased LDL cholesterol levels, and premature atherosclerosis and cardiovascular disease. Aortic valve peak velocity (AV Vmax) may be considered as a subclinical marker of atherosclerosis in the aortic valve. Lipoprotein (a) (Lp[a]) is proposed as an independent risk factor for CVD, and may mediate atherosclerosis, at least partly, by its antifibrinolytic and inflammatory properties. Furthermore, Lp(a) has been associated with aortic stenosis. However, less is known about the effect of Lp(a) on atherosclerotic markers in patients with primarily genetic verified FH. We aimed to investigate atherosclerotic markers in FH subjects with and without high Lp(a) levels and healthy controls.
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