Abstract
ObjectivesTo study the serum Procalcitonin (PCT) level in inflammatory arthritis including gouty arthritis (GA), Rheumatoid arthritis (RA), and ankylosing spondylitis (AS) without any evidence of infection were evaluated the possible discriminative role of PCT in gouty arthritis susceptibility in southern Chinese Han Population.Material and MethodsFrom Feb, 2012 to Feb, 2015, 51 patients with GA, 37 patients with RA, 41 patients with AS and 33 healthy control were enrolled in this study with no evidence of infections. The serum level of PCT (normal range < 0.05 ng/ml) was measured by electrochemiluminescence immunoassay (ECLIA). Disease activity was determined by scores of VAS (4.07 ± 1.15), DAS28 (4.97 ± 1.12), and ASDAS (2.97 ± 0.81) in GA, RA and AS groups respectively. Other laboratory parameters such as, serum creatinine (CRE), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), uric acid (UA) and white blood cells (WBC) were extracted from medical record system.ResultsSerum PCT level was predominantly higher in gouty arthritis than in RA and AS patients, especially in the GA patients with tophi. PCT was significantly positively correlated with VAS, CRP and ESR in gouty arthritis and CRP in AS. PCT also had positive correlation-ship with ESR, DAS28 and ASDAS in RA and AS patients respectively, but significant differences were not observed.ConclusionsThese data suggested that PCT is not solely a biomarker for infection, but also an indicator in inflammatory arthritis, especially in gouty arthritis.
Highlights
Procalcitonin (PCT) is 116 amino acid polypeptide precursors to the calcium regulating hormone calcitonin and its synthesis is regulated by C cell of the thyroid gland, Calc-1 gene located on chromosome-11
Serum PCT level was predominantly higher in gouty arthritis than in rheumatoid arthritis (RA) and ankylosing spondylitis (AS) patients, especially in the GA patients with tophi
PCT was significantly positively correlated with Visual analogue scales (VAS), C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) in gouty arthritis and CRP in AS
Summary
Procalcitonin (PCT) is 116 amino acid polypeptide precursors to the calcium regulating hormone calcitonin and its synthesis is regulated by C cell of the thyroid gland, Calc-1 gene located on chromosome-11. GA is a repeated episode of inflammatory condition secondary to the high concentration of uric acid in blood associated with crystal deposition in connective tissues and presents as acute and chronic arthritis typically involvement of first metatarsal joint followed by other multiple joints, tophi, urolithiasis and renal disease [4]. It is one of the most common forms of arthritis in the US survey, the prevalence of gout among the US adults was 3.9% [5,6]. Our data indicates that PCT is a marker of infectious state, and a predictor for acute arthritis, especially in GA
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