High level HIV viremia associated with intestinal infections

Abstract

Event Abstract Back to Event High level HIV viremia associated with intestinal infections Caciane P. Sousa1*, Shayara L. Ciríaco2, Talyta Dolores B. César2, Ceciane P. Sousa3 and Carlos Brites4 1 Federal University of Piauí, Department of Microbiology, Immunology and Parasitology, Brazil 2 Federal University of Piauí, Pharmacy Course, Brazil 3 Federal University of Piauí, Human Sciences Center, Brazil 4 Federal University of Bahia, Virology Research Laboratory, Brazil The human immunodeficiency virus (HIV) induces a chronic activation of the immune system that may favor to the progression to HIV infection and the onset of several comorbidities correlated with this infection. We analyze the immunological profile of hospitalized patients with comorbidities associated the HIV infection from Teresina, Piauí, Brazil in 2012. The blood samples of the 42 hospitalized patients were processed and analyzed to CD4+ and CD8+ T-cells counts by flow cytometry and the HIV viral load were examined using real-time quantitative polymerase chain reaction. The results were analyzed according to city, gender, educational level, socioeconomic status and manifested comorbidities. These results demonstrated that most of patients were from the city of Teresina (50%). There was predominance of males and unmarried (61.9% and 67.29%, respectively) and in those with low educational and socioeconomic levels (31%). The comorbidities most frequent manifested by hospitalized patients have been pneumonia (26,2%) followed by both toxoplasmosis (23,8%) and intestinal infections (23,8%). Among these comorbidities, the intestinal infections have shown the lowest mean of the CD4+ and CD8+ T-cells counts (79,5 and 787,7 cell/mm³, respectively) and the highest mean of the HIV viral load (180,993 copies/mL). Thus, intestinal infections have been associated to immune response more deteriorated that may favor to the progression to HIV infection. Keywords: HIV, CD4+ T-cells, Viral Load, comorbidities, Intestinal infections Conference: IMMUNOCOLOMBIA2015 - 11th Congress of the Latin American Association of Immunology - 10o. Congreso de la Asociación Colombiana de Alergia, Asma e Inmunología, Medellin, Colombia, 13 Oct - 16 Oct, 2015. Presentation Type: Poster Presentation Topic: Infectious and parasitic diseases Citation: Sousa CP, Ciríaco SL, César TB, Sousa CP and Brites C (2015). High level HIV viremia associated with intestinal infections. Front. Immunol. Conference Abstract: IMMUNOCOLOMBIA2015 - 11th Congress of the Latin American Association of Immunology - 10o. Congreso de la Asociación Colombiana de Alergia, Asma e Inmunología. doi: 10.3389/conf.fimmu.2015.05.00171 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 29 May 2015; Published Online: 14 Sep 2015. * Correspondence: PhD. Caciane P Sousa, Federal University of Piauí, Department of Microbiology, Immunology and Parasitology, Teresina, Piauí, Brazil, cacianeportela@yahoo.com.br Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Caciane P Sousa Shayara L Ciríaco Talyta Dolores B César Ceciane P Sousa Carlos Brites Google Caciane P Sousa Shayara L Ciríaco Talyta Dolores B César Ceciane P Sousa Carlos Brites Google Scholar Caciane P Sousa Shayara L Ciríaco Talyta Dolores B César Ceciane P Sousa Carlos Brites PubMed Caciane P Sousa Shayara L Ciríaco Talyta Dolores B César Ceciane P Sousa Carlos Brites Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.