Abstract
Kinetic inertness is a key property for a Gd-based contrast agent. The Gd(III) complex of a cyclohexyl-fused AAZTA derivative shows the highest kinetic inertness for non-macrocyclic bis hydrated (q = 2) Gd(III)-complexes with a dissociation half-life of 91 years under physiological conditions, very close to that of macrocyclic clinically approved contrast agents. It also shows optimal relaxometric performance (r1 = 8.3 mM(-1) s(-1) at 20 MHz and 25 °C) due to the presence of two inner sphere water molecules in fast exchange with bulk water and not displaced by endogenous anions.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
