Abstract
BackgroundInflammatory activation has been associated with the severity and progression of chronic heart failure (CHF). Although cardiac rehabilitation is an important therapy, acute bouts of exercise may lead to increases in pro-inflammatory cytokines with exercise intensity mediating these changes.ObjectiveTo evaluate the acute inflammatory response in patients living with CHF during a randomized trial following Steady State (SS) or High Intensity Interval (HIIT) training.MethodsPatients living with CHF (n = 14) were stratified (for body mass and aerobic power) and randomized into SS and HIIT cycle exercise. The HIIT exercise training involved 2 min work:recovery phases at 90:40% heart rate reserve. The SS exercise training involved continuous exercise at 65% of heart rate reserve (matched total work). Acute inflammatory markers were evaluated (via ELISA) at baseline, immediately following the bout, and at 6, 24, and 48 h post-exercise.ResultsThere was limited differences in the changes in inflammatory biomarkers across time between the HIIT and SS groups. Both groups experienced a significant (p < 0.05) change in Interleukin-6 immediately post-exercise.ConclusionsA single bout of HIIT or SS does not result in excessive inflammatory activation in CHF patients. Acute HIIT and SS result in similar changes in inflammatory markers. These findings have important implications for exercise training and rehabilitation programs in persons living with CHF.
Highlights
Inflammatory activation with increased plasma/serum cytokine levels has been described as an important factor for the progression of chronic heart failure (CHF) [1, 2]
To our knowledge this study is the first randomized trial to evaluate the acute and temporal effects of HIIT in comparison to traditional SS exercise training on markers of inflammatory function in persons living with CHF
The average training intensity was controlled between the HIIT and SS groups, further highlighting the importance of understanding exercise intensity as it relates to inflammatory markers in persons living with CHF
Summary
Inflammatory activation with increased plasma/serum cytokine levels has been described as an important factor for the progression of chronic heart failure (CHF) [1, 2]. Cytokines appear to act as catabolic factors in the pathogenesis of skeletal muscle wasting and cardiac cachexia [3,4,5]. This has important implications as muscle mass is an important determinant of exercise and functional capacity [6]. Inflammatory activation has been associated with the severity and progression of chronic heart failure (CHF). Cardiac rehabilitation is an important therapy, acute bouts of exercise may lead to increases in pro-inflammatory cytokines with exercise intensity mediating these changes
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