High‐intensity Interval Training Enhanced Platelet Mitochondrial Bioenergetics in Patients with Heart Failure

Abstract

Mitochondrial functionalities in platelets involve the cellular bioenergetics and thrombogenesis. This study elucidates how high‐intensity interval training (HIIT) affects systemic aerobic capacity and platelet mitochondrial bioenergetics in the patients with heart failure (HF). Thirty‐four HF patients with were randomized to engage HIIT (3‐minute intervals at 40% and 80% VO2peak, n=17) for 30 minutes/day, 3 days/week for 12 weeks, or to a general health care group (GHC, n=17) that did not received exercise intervention. Systemic aerobic capacity (i.e., peak O2 consumption, VO2peak) and platelet mitochondrial O2 consumption rate (OCR) in the HF patients were measured using automatic gas analysis and high‐resolution respirometry, respectively. The experimental results demonstrated that the HIIT group exhibited higher VO2peak and O2 uptake efficiency slope, as well as, lower VE‐VCO2 slope following the 12‐week intervention, compared to those of the GHC group. Moreover, the HIIT, but not the GHC, regimen (i) increased the capacities for the maximal and reserve of OCR, (ii) enhanced the Complex I‐ and II‐mediated OCRs, and (iii) elevated the bioenergetics health index in platelets. Additionally, the VO2max levels were positively correlated with the maximal and reserve capacities of OCR and Complex I‐ and II‐mediated OCRs in platelets. Hence, the HIIT regimen improves aerobic fitness and ventilatory efficiency, which is accompanied by enhanced capacity for platelet mitochondrial bioenergetics in patients with HF.Support or Funding InformationNational Science Council of Taiwan (grant number NSC 106‐2314‐B‐182 ‐048 ‐MY3).This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.