Abstract
This study evaluated the relationship between synchronous multiple gastric cancer and other primary malignancies. During 2002–2013, 1094 consecutive surgically treated gastric cancer patients were enrolled. Preoperatively, we performed total colonoscopy and whole-body computed tomography. When malignancies in other organs were suspected, detailed organ-specific examinations were performed. Synchronous multiple gastric cancer occurred in 102 patients (9.3%)which was frequently observed in patients with preoperative other primary malignancies (p < 0.001). Preoperative other primary malignancy was an independent risk factor for synchronous multiple gastric cancer (p = 0.001; hazard ratio: 2.145, 95% confidence interval: 1.354–3.399) and an independent prognostic factor of overall survival in patients undergoing gastrectomy with curative intent (p = 0.021; hazard ratio: 1.481, 95% confidence interval: 1.060–2.070). Thus, patients with preoperative other primary malignancies have a high risk of synchronous multiple gastric cancer. Careful preoperative examination is recommended to improve survival.
Highlights
The detection of multiple lesions of gastric cancer (GC) has been increasing along with advances in endoscopic and pathologic examinations
This study evaluated the relationship between synchronous multiple gastric cancer and other primary malignancies
Synchronous multiple gastric cancer occurred in 102 patients (9.3%)which was frequently observed in patients with preoperative other primary malignancies (p < 0.001)
Summary
The detection of multiple lesions of gastric cancer (GC) has been increasing along with advances in endoscopic and pathologic examinations. Accessory lesions are generally not considered as a prognostic factor in SMGC patients [2, 3]. GC patients sometimes present other primary malignancies (OPMs), in the colon [4]. Recent studies have demonstrated an association between SMGC and OPMs, and found that this association was frequently observed in colorectal cancer patients [5, 6]. The exact relationship between SMGC and OPMs remains unclear, and it would be of clinical benefit to clarify what types of OPMs occur in SMGC patients. With this in mind, we performed the present multicenter retrospective cohort study to clarify the relationship between SMGC and OPMs
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