Abstract
CD27 neg T cells are found only among CD4 pos-CD45RO pos T cells and represent a T cell subset functionally distinct from CD27 pos T cells. We examined CD4 posCD45RO pos T cells that were sorted into CD27 neg and CD27 pos populations for their cytokine production in response to different activation pathways. We found that CD27 neg T cells are characterized by high IL-4 and low IL-2 production, regardless of whether the cells were activated through CD3 plus CD28, CD2 plus CD28, or PHA plus PMA. However, subpopulation-specific patterns of cytokines were the clearest demonstrable following CD2 plus CD28 stimulation. We conclude from these data that high IL-4 production is a stable phenotype of CD27 neg T cells.
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