Abstract
Background and objectives: Evidence shows that shift work may be correlated with insulin resistance (IR). Therefore its estimation in clinical and prevention practice is of great significance. A cross-sectional study was performed to examine the Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) Index among healthcare shift workers (HCSW). Materials and Methods: A total of 272 healthcare workers (HCWs) were invited to participate in the study within an occupational surveillance framework, 137 were HCSW while 135 were healthcare non-shift workers (HCNSW). Fasting glucose, insulin, and HOMA-IR Index were evaluated in each participant and correlated with shift workers. Results: Indicators of glucose metabolism were significantly higher in HCSW p < 0.001, and logistic regression analysis confirmed a significant positive association between increased values of HOMA-IR Index and shift workers (p < 0.05). Conclusions: Shift work could be a risk factor in developing insulin resistance and metabolic syndrome.
Highlights
Shift work (SW) is a work plan involving irregular or atypical hours, compared to those of a standard daytime work timetable [1]
The spectrum of metabolic disorders associated with insulin resistance (IR) extends to pathologies other than type 2 diabetes and comprises dyslipidemia, hypercoagulability, hypertension, and inflammation, all of which are connected to the metabolic syndrome and are risk factors for cardiovascular illness [19]
The present study aimed to examine the Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) Index among healthcare shift workers (HCSW) in order to contribute to evaluating the economic burden of metabolic syndrome (MS) in the shift workers population
Summary
Shift work (SW) is a work plan involving irregular or atypical hours, compared to those of a standard daytime work timetable [1]. Recent epidemiological studies have highlighted that SW is connected to an augmented risk of type 2 diabetes [11,12,13,14]. The spectrum of metabolic disorders associated with IR extends to pathologies other than type 2 diabetes and comprises dyslipidemia, hypercoagulability, hypertension, and inflammation, all of which are connected to the metabolic syndrome and are risk factors for cardiovascular illness [19]. Model Assessment-Insulin Resistance (HOMA-IR) is extensively used as a method to assess MS. The HOMA-IR index computation is based on the determination of fasting glucose and insulin values [20,21]. The present study aimed to examine the HOMA-IR Index among healthcare shift workers (HCSW) in order to contribute to evaluating the economic burden of MS in the shift workers population
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