Abstract
BackgroundAccurate information on the geographical distribution of malaria is important for efficient resource allocation. The Lao People's Democratic Republic has experienced a major decline in malaria morbidity and mortality in the past decade. However, efforts to respond effectively to these changes have been impeded by lack of detailed data on malaria distribution. In 2008, a countrywide survey on Plasmodium falciparum diagnosed in health centres and villages was initiated to develop a detailed P. falciparum risk map with the aim to identify priority areas for malaria control, estimate population at risk, and guide resource allocation in the Lao People's Democratic Republic.MethodsP. falciparum incidence data were collected from point-referenced villages and health centres for the period 2006-2008 during a country-wide survey between December 2008 and January 2009. Using the highest recorded annual rate, continuous surfaces of P. falciparum incidence were produced by the inverse distance weighted interpolation technique.ResultsIncidence rates were obtained from 3,876 villages and 685 health centres. The risk map shows that P. falciparum is highly heterogeneous in the northern and central regions of the country with large areas of no transmission. In the southern part, transmission is pervasive and the risk of P. falciparum is high. It was estimated that 3.4 million people (60% of the population) live at risk of malaria.ConclusionsThis paper presents the first comprehensive malaria risk map of the Lao People's Democratic Republic based entirely on empirical data. The estimated population at risk is substantially lower than previous estimates, reflecting the presence of vast areas with focal or no malaria transmission as identified in this study. These findings provide important guidance for malaria control interventions in the Lao People's Democratic Republic, and underline the need for detailed data on malaria to accurately predict risk in countries with heterogeneous transmission.
Highlights
Accurate information on the geographical distribution of malaria is important for efficient resource allocation
Significant reductions have been reported after recent investments in malaria control, in particular the large-scale introduction of artemisinin-based combination therapy (ACT) and insecticide-treated nets (ITNs), in conjunction with socio-economic and environmental changes
A standard data collection form was prepared for each district with the following information: Name of all health centres and villages with RDTs or microscopy in the district, unique administrative code for each village and health centre, date when RDTs were first received, population, number of persons tested for malaria and number of confirmed P. falciparum cases by month between 2006 and 2008
Summary
Accurate information on the geographical distribution of malaria is important for efficient resource allocation. The Lao People’s Democratic Republic has experienced a major decline in malaria morbidity and mortality in the past decade. Efforts to respond effectively to these changes have been impeded by lack of detailed data on malaria distribution. In 2008, a countrywide survey on Plasmodium falciparum diagnosed in health centres and villages was initiated to develop a detailed P. falciparum risk map with the aim to identify priority areas for malaria control, estimate population at risk, and guide resource allocation in the Lao People’s Democratic Republic. Detailed knowledge of the geographical extent of malaria and intensity of transmission can guide decisions on appropriate and. Transmission of malaria is perennial, but with large seasonal and regional variations. In 2008, only 11 deaths among 18,743 confirmed malaria cases were reported (population 6 million), compared with 600 deaths and 70,000 confirmed cases in 1997 (routine malaria surveillance reports, Center for Malariology, Parasitology and Entomology (CMPE), unpublished data)
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