Abstract
Fructose has several interactions in man, including intolerance and promotion of some diseases. However, fructose in fruits and in prebiotics may be associated with benefits. Adaptation to regular fructose ingestion as defined for lactose could support a beneficial rather than a deleterious effect. This study was undertaken to evaluate symptomatic response and potential underlying mechanisms of fecal bacterial change and breath hydrogen response to short term regular fructose supplementation. Forty-five participants were recruited for a 3 day recall diet questionnaire and a 50 g fructose challenge. Breath hydrogen was measured for 4.5 hrs and symptoms were recorded. Thirty-eight subjects provided stool samples for analysis by selective culture of 4 groups of bacteria, including bifidobacteria and lactobacilli. Intolerant subjects returned a second time 15 days later. Ten of these served as controls and 16 received 30 g fructose twice a day. Ten of the latter returned 27 days later, after stopping fructose for a third challenge test. Student’s paired, unpaired t-tests and Pearson correlations were used. Significance was accepted at P
Highlights
Glucose and galactose represent the main monosaccharides utilized by man and most mammals
Following regular lactose consumption a second Measured hydrogen or fecal bacteria were relat- changes of interest were focused on bifidobacchallenge test is performed and both a reduc- ed to intakes
Comparison of daily fructose based on high (≥20 g/d, N 5) or low (
Summary
Gastroenterology, Mcgill University School of Medicine, Montreal, QC, Canada 2Department of Microbial Biotechnology, Genetic Engineering and Biotechnology. Glucose and galactose represent the main monosaccharides utilized by man and most mammals. There is a dose dependent intolerance to consumption of fruc-
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