Abstract

This study aims at high-frequency ultrasound image quality assessment for computer-aided diagnosis of skin. In recent decades, high-frequency ultrasound imaging opened up new opportunities in dermatology, utilizing the most recent deep learning-based algorithms for automated image analysis. An individual dermatological examination contains either a single image, a couple of pictures, or an image series acquired during the probe movement. The estimated skin parameters might depend on the probe position, orientation, or acquisition setup. Consequently, the more images analyzed, the more precise the obtained measurements. Therefore, for the automated measurements, the best choice is to acquire the image series and then analyze its parameters statistically. However, besides the correctly received images, the resulting series contains plenty of non-informative data: Images with different artifacts, noise, or the images acquired for the time stamp when the ultrasound probe has no contact with the patient skin. All of them influence further analysis, leading to misclassification or incorrect image segmentation. Therefore, an automated image selection step is crucial. To meet this need, we collected and shared 17,425 high-frequency images of the facial skin from 516 measurements of 44 patients. Two experts annotated each image as correct or not. The proposed framework utilizes a deep convolutional neural network followed by a fuzzy reasoning system to assess the acquired data’s quality automatically. Different approaches to binary and multi-class image analysis, based on the VGG-16 model, were developed and compared. The best classification results reach accuracy for the first, and for the second analysis, respectively.

Highlights

  • During the last decades, high-frequency ultrasound (HFUS, >20 MHz) has opened up new diagnostic paths in skin analysis, enabling visualization and diagnosis of superficial structures [1,2]

  • To assess all the experiments, we used the external 5-fold cross-validation, and the non-testing remaining data were divided into training and validation subsets (4:1 ratio)

  • Since the correct acquisition of US and HFUS images is essential for further accurate data analysis, in this study, we describe possible solutions aiming at ‘correct’ image identification

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Summary

Introduction

High-frequency ultrasound (HFUS, >20 MHz) has opened up new diagnostic paths in skin analysis, enabling visualization and diagnosis of superficial structures [1,2]. It has gained popularity in various areas of medical diagnostics [3,4] and is commonly used in medical practice [5]. In oncology, it helps in the determination of skin tumor depth, prognosis, and surgical planning [1,6], enabling differentiation between melanoma, benign nevi, and seborrheic keratoses [7]. Ciapoletta et al [10]

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