Abstract
In a previous work, we showed the potential of an in vitro high frequency ultrasound device to describe the blood clotting process. The parameters were simultaneously estimated in double transmission (DT) and in backscattering (BSC) modes. We showed that BSC-mode and DT-mode parameters were complementary to give a fine description of blood coagulation process in terms of mechanical properties (blood solidification) and spatial distribution of blood components (formation RBC aggregates). In the present paper, our purpose was first to refine our results on the phenomenon of the red blood cell (RBC) aggregation, and to estimate inter-individual and intra-individual variations of these parameters describing the blood clotting process according to several protocols. By comparing intra- and inter-individual variations, discriminating potential of the acoustical parameters was assessed.
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