Abstract
To the Editor: Clinical trials in the field of transcranial ultrasound thrombolysis used 2-MHz Doppler devices. Available in vitro and animal studies only used ultrasound frequencies in lower ranges. In this context the highest evaluated frequency was 1 MHz,1–4⇓⇓⇓ which was less sufficient when compared with lower frequencies in the kHz range.1,2,5⇓⇓ In our study, ultrasound with a maximum acoustic intensity of 0.72 W/cm2 (Food and Drug Administration limit) was used. Clots were focused with B-mode, which was then switched off, and sonication was performed only with 1.8-MHz Doppler ultrasound. The goal was to evaluate if high-frequency ultrasound …
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