Abstract
Local cortical release of vasoactive intestinal polypeptide (VIP) was measured using a sensitive radioimmunoassay following direct electrical stimulation of the facial nerve in the anaesthetised cat. During activation of the facial nerve dilator pathway VIP was released at the cortex and collected into a physiological superfusate, its concentration increasing from 4.2 ± 1.2 to 15.5 ± 2.4 pmol/l. Administration of the nicotinic ganglion blocking agent hexamethonium (10 mg/kg i.v.) eliminated this response demonstrating that the release is mediated via an autonomic ganglion. Given previous experiments that have demonstrated that stimulation of the facial nerve leads to a neurogenically mediated dilatation of the cerebral vasculature, these data further implicate VIP as the transmitter in this pathway.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
