High frequency oscillation ventilation treats respiratory distress syndrome of premature

Abstract

Objective To explore the application of high frequency oscillation in the area of respiratory distress syndrome (RDS) of premature. Methods A total of 101 cases with RDS of premature was collected who needed the machine support in neonatal intensive care unite (NICU) during 2010.11.01-2011.10.30. Forty one cases (high frequency oscillation group) received the high frequency oscillation, while 60 cases received the common ventilation (Control Mechanical Ventilation group; control group). The results of blood gas analysis were recorded before ventilation, after ventilation for 2 hours, after ventilation for 12 hours, and after ventilation for 24 hours. The chest X-Ray and the complication were examined. Results The result of the blood-gas before ventilation, after ventilation for 2 hours, after ventilation for 12 hours, and after ventilation for 24 hours, FIO2, PO2, PCO2, and Pa(A-a) were statistically analyzed, and F-value was 16.202, 14.764, 16.135, 8.434, P<0.01. For chest X-ray in high frequent oscillation group, there were 36 cases who had improved after ventilation 24 hours and all had improved after ventilation 72 hours; however, in common ventilation group, there were 30 cases who had improved after 24 hours and 50 cases had improved after 72 hours, χ2=15.372 and 7.584, P<0.01, there was statistical difference for two groups. However, there were not different in cerebral injury /healing damage and retinopathy of prematurity (ROP) for two groups. Conclusions High frequency oscillation is an effective way to treat RDS of premature. Key words: High-frequency ventilation; Respiratory distress syndrome, newborn/TH