Abstract
University of Pittsburgh Department of Critical Care Medicine: Evidence-Based Medicine Journal Club, edited by Sachin Yende
Highlights
Previous trials suggesting that high-frequency oscillatory ventilation (HFOV) reduced mortality among adults with the acute respiratory distress syndrome (ARDS) were limited by the use of outdated comparator ventilation strategies and small sample sizes
Ventilator management is a key component of acute respiratory distress syndrome (ARDS) management
In the United States, HFOV has been sporadically used in adult ARDS patients after the US Food and Drug Administration cleared it for pediatric use in the 1990s
Summary
Objective: The aim of the study was to compare HFOV with a conventional ventilation strategy that used low tidal volumes and high levels of positive end-expiratory pressure in patients with new-onset, early (
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