Abstract
Meeting abstracts Malignant transformation of cells is associated with downregulation of HLA class I APM components in most of the tumors. These defects are clinically relevant, since they are frequently associated with the clinical course of the disease. Only in a few tumors malignancy is
Highlights
Malignant transformation of cells is associated with downregulation of HLA class I antigen processing machinery (APM) components in most of the tumors
The frequency of HLA class I APM component upregulation and its clinical significance in hepatocellular carcinoma (HCC) are not known. These topics were investigated in the present study, since the resulting information may contribute to assess the therapeutic efficacy of T cell-based immunotherapy for the treatment of HCC
Twenty-one surgically resected primary HCC tumors and autologous adjacent nonmalignant tissues were stained with a unique panel of monoclonal antibodies which recognize HLA class I APM components
Summary
Malignant transformation of cells is associated with downregulation of HLA class I APM components in most of the tumors. High frequency of HLA class I antigen processing machinery (APM) component upregulation in primary hepatocellular carcinoma tumors In a few tumors malignancy is associated with the upregulation of HLA class I antigens.
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