Abstract
High Foetal Haemoglobin in Sickle Cell Disease: Not so Protective?
Highlights
The distribution of HbF among HbF-containing red cells (F-cells) varies between sickle cell anaemia (SCA) individuals (Horiuchi et al, 1995), and this study highlights recent suggestions that the distribution of HbF among red cells is more important than the total amount of HbF produced, in terms of its protective effects (Steinberg et al, 2014), as the concentration of HbF in each F-cell must be sufficient to interfere in HbS polymerisation and reduce the symptoms of SCA (Steinberg et al, 2014)
The author declares no conflicts of interest relevant to this commentary
Costa for the valuable discussion regarding the preparation of this commentary
Summary
The distribution of HbF among HbF-containing red cells (F-cells) varies between SCA individuals (Horiuchi et al, 1995), and this study highlights recent suggestions that the distribution of HbF among red cells is more important than the total amount of HbF produced, in terms of its protective effects (Steinberg et al, 2014), as the concentration of HbF in each F-cell must be sufficient to interfere in HbS polymerisation and reduce the symptoms of SCA (Steinberg et al, 2014).
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