Abstract
K ATP channel in vascular smooth muscle cell (VSMC) is closely linked to the etiology of hypertension. The aim of this study was to investigate effect of the high-fat diet-induced obesity on K ATP channel and blood pressure. Obesity was induced by a 24-week high-fat diet feeding in rats. Function and expression of K ATP channel in mesenteric arteries were examined using myography system, patch clamp and Western blotting. We show that high-fat diet increased blood pressure, decreased K ATP channel-mediated relaxation responses and currents, and down-regulated K ATP expression in VSMC. In conclusion, diet-induced obesity impairs K ATP channels in VSMC, which may underscore obesity-triggered increase in blood pressure.
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