High Fat Diet- Induced Neurotoxicity Alters Following vitamin E and C Administration in Hippocampus of Male Rats

Abstract

Background: Consumption of a high fat diet (HFD) leads to spatial memory impairment and hippocampal cell death. Objectives: The present study evaluated the capacity of antioxidant supplementation to interact with the effects of high fat diet at the molecular level. Methods: Animal groups were exposed to HFD for 9 months with free access to high fat diet and high fat diet with antioxidant supplementation (vitamin E, vitamin C, and Astaxanthin). At the end of the study, brains were removed and the level of brain-derived neurotrophic factor (BDNF), Tropomyosin receptor kinase B (Trk β), synapsin I, and the transcription factor Cyclic AMP Response Element Binding protein (CREB) and caspase-3 expression in the hippocampi were measured. Results: Antioxidants protected against HFD-induced cell death and the up-regulation of BDNF, Trk β, Synapsin I, CREB, and Caspase-3. Conclusions: This data suggested the possible benefit of vitamin E and C in the treatment of neurotoxicity among, those with a HFD.