Abstract
Introduction: Nonsteroidal anti-inflammatory drugs (NSAIDs) act by inhibiting cyclooxygenase, an enzyme that regulates production of prostanoids including the vasoconstrictor thromboxane and the vasodilator prostacyclin. However, their effect on the cardiovascular system remains controversial. Most studies on the cardiovascular risks of selective and non-selective NSAIDs have not adjusted for comorbidities such as diabetes and hypercholesterolemia. We used a swine model of chronic myocardial ischemia to determine whether a high-fat diet alters the cardiovascular effects of the non-selective NSAID naproxen.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
