High Expression of SOD2 Protein Is a Strong Prognostic Factor for Stage IIIB Squamous Cell Cervical Carcinoma.

Maria Cecília Ramiro Talarico,Larissa Bastos Eloy Da Costa,Rafaella Almeida Lima Nunes,Luiz Carlos Zeferino,Sérgio Carlos Barros Esteves,Lara Termini,Gabriela Ávila Fernandes Silva,Luis Otávio Zanatta Sarian,Marcella Regina Cardoso

doi:10.3390/antiox10050724

Abstract

High superoxide dismutase 2 (SOD2) expression is associated with a poor prognosis at many cancer sites, the presence of metastases, and more advanced cervical cancer. This study aims to determine whether SOD2 protein expression is associated with the prognosis of stage IIIB cervical carcinoma. Methods: sixty-three patients with stage IIIB squamous cell cervical carcinoma were included. The evaluation of SOD2 expression by immunohistochemistry was based on a positive cell ratio score and the staining intensity score. Taking disease recurrence and death as endpoints, receiver operating characteristic curves were used to discriminate between high and low SOD2 expression. Results: high SOD2 expression was associated with recurrence (p = 0.001), distant recurrence (p = 0.002), and death (p = 0.005). A multivariate analysis showed that patients with high SOD2 expression had a threefold increased risk for recurrence (HR = 3.16; 1.33–7.51) and death (HR = 2.98; 1.20–7.40) compared with patients who had low SOD2 expression. Patients with high SOD2 expression had shorter disease-free survival (p = 0.001) and overall survival (p = 0.003) than patients with low SOD2 expression. Conclusion: high SOD2 expression is a strong prognostic factor for stage IIIB squamous cell carcinoma of the cervix and could be used as a prognostic marker in women with cervical carcinoma.

Highlights

Licensee MDPI, Basel, Switzerland.Cervical cancer is a very common malignant neoplastic disease, which is treatable even at advanced stages and has more than 600,000 new cases diagnosed each year worldwide [1].The development of clinical tools for the diagnosis, treatment, and follow-up of malignant neoplasms may help improve the outcome and may benefit patients.Currently, HPV testing, cytology, or a combination of HPV testing cytology are the major means to screen a population for cervical cancer [2]
The aim of this study was to determine whether superoxide dismutase 2 (SOD2) protein expression is associated with the prognosis of stage IIIB cervical carcinoma
The univariate analysis of data from our study showed that high SOD2 expression was associated with reduced disease-free survival (DFS) and overall survival (OS) in patients with cervical cancer

Summary

Introduction

Licensee MDPI, Basel, Switzerland.Cervical cancer is a very common malignant neoplastic disease, which is treatable even at advanced stages and has more than 600,000 new cases diagnosed each year worldwide [1].The development of clinical tools for the diagnosis, treatment, and follow-up of malignant neoplasms may help improve the outcome and may benefit patients.Currently, HPV (human papillomavirus) testing, cytology, or a combination of HPV testing cytology are the major means to screen a population for cervical cancer [2]. Cervical cancer is a very common malignant neoplastic disease, which is treatable even at advanced stages and has more than 600,000 new cases diagnosed each year worldwide [1]. The development of clinical tools for the diagnosis, treatment, and follow-up of malignant neoplasms may help improve the outcome and may benefit patients. HPV (human papillomavirus) testing, cytology, or a combination of HPV testing cytology are the major means to screen a population for cervical cancer [2].

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