High expression of serum GST-π/CypA aids the diagnosis of acute cerebral infarction and predicts short-term poor prognosis

Abstract

ObjectiveThe study examined the diagnostic and prognostic value of GST-π combined with CypA in acute cerebral infarction (ACI). MethodsThe study included 115 ACI patients and 85 healthy people. Expression patterns of serum GST-π and CypA were detected using ELISA. The diagnostic efficiency of GST-π, CypA, and GST-π combined with CypA on ACI was assessed by ROC curves. Pathological parameters were further analyzed using the Fisher test, t test, and one-way ANOVA. ACI patients were subsequently assigned into severe, moderate, and mild groups under the National Institutes of Health Stroke Scale (NIHSS), followed by Pearson analysis of the correlation between GST-π and CypA and NIHSS scores. The prognosis was evaluated by follow-up using modified Rankin Scale. Correlation between GST-π/CypA expression and ACI prognosis was predicted using a survival curve, and the predictive value of GST-π/CypA on ACI prognosis was assessed with a ROC curve. Lastly, the independent correlation of GST-π and CypA with poor ACI prognosis was analyzed with Logistics multivariate regression analysis. ResultsGST-π and CypA were both highly-expressed in ACI patients. GST-π combined with CypA could better aid ACI diagnosis. Expressions of GST-π and CypA were positively correlated with NIHSS scores of ACI patients. High expressions of GST-π and CypA were correlated with poor short-term prognosis of ACI patients. ConclusionSerum GST-π combined with CypA aids diagnosis and predicts poor short-term prognoses of ACI. Data AvailabilityThe data that support the findings of this study are available from the corresponding author upon reasonable request.