Abstract
The nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA. Many studies have reported that NEAT1 plays critical oncogenic roles and facilitates tumorigenesis of various human cancers. High NEAT1 expression is associated with a poor prognosis in cancer patients. This meta-analysis was conducted to assess the association between NEAT1 levels and survival times of cancer patients. Overall survival (OS) was the primary endpoint. Thirteen publications with 1,496 cancer patients from 5 databases (PubMed, EMBASE, Cochrane Library, Wiley Online Library, and Medline) met the criteria for this meta-analysis. Results of the analysis showed that NEAT1 expression in human cancer was significantly associated with OS (hazard ratio [HR]=1.53, 95% confidence interval [CI]: 1.39–1.68), including digestive system tumor (HR=1.54, 95% CI: 1.37–1.73) and respiratory carcinomas (HR=1.44, 95% CI: 1.11–1.85). The results also indicated that NEAT1 expression was highly associated with tumor size (>3 cm vs. ≤3 cm; odds ratio [OR]=2.51, 95% CI: 1.27–4.99; p=0.009), TNM stage (III+IV vs. I+II; OR=4.17, 95% CI: 2.42–7.18; p=0.00001), and distant metastasis (OR=2.73, 95% CI: 1.28–5.79; p=0.01). However, there was no significant association with differentiation (poor vs. well + moderate, OR=1.45, 95% CI: 0.72–2.91) and lymph node metastasis (OR=1.39, 95% CI: 0.54–3.60). This meta-analysis showed that NEAT1 expression may be a useful biomarker for predicting a poor prognosis in patients with cancer.
Highlights
Long non-coding RNA (LncRNA) is a class of non-coding RNA, and has more than 200 nucleotides [1]
Results of the analysis showed that nuclear paraspeckle assembly transcript 1 (NEAT1) expression in human cancer was significantly associated with overall survival (OS), including digestive system tumor (HR=1.54, 95% CI: 1.37–1.73) and respiratory carcinomas (HR=1.44, 95% CI: 1.11–1.85)
No significant publication bias was observed across studies. This meta-analysis is the first to evaluate the association between NEAT1 levels and cancer prognosis
Summary
Long non-coding RNA (LncRNA) is a class of non-coding RNA, and has more than 200 nucleotides [1]. Few LncRNAs, such as AFAPI-ASI, MALAT-1, and UCA1 have been confirmed to play a significant role in cancer progression [5,6,7,8]. The nuclear paraspeckle assembly transcript 1 (NEAT1) is a newly identified nuclear-restricted LncRNA and is located on chromosome 11 (11q13.1). It is an essential component of nuclear paraspeckles [10, 11], and has been confirmed to overexpress in many human cancers, including prostate, lung, and breast cancers [12,13,14]. NEAT1 might act as a potential diagnostic biomarker and prognostic factor This meta-analysis is the www.impactjournals.com/oncotarget first to explore the correlation between NEAT1 expression and prognosis of cancer patients
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