Abstract
Background and Objectives: Krüppel-like transcription factor 10 (KLF10) plays a vital role in regulating cell proliferation, including the anti-proliferative process, activation of apoptosis, and differentiation control. KLF10 may also act as a protective factor against oral cancer. We studied the impact of KLF10 expression on the clinical outcomes of oral cancer patients to identify its role as a prognostic factor in oral cancer. Materials and Methods: KLF10 immunoreactivity was analyzed by immunohistochemical (IHC) stain analysis in 286 cancer specimens from primary oral cancer patients. The prognostic value of KLF10 on overall survival was determined by Kaplan–Meier analysis and the Cox proportional hazard model. Results: High KLF10 expression was significantly associated with male gender and betel quid chewing. The 5-year survival rate was greater for patients with high KLF10 expression than for those with low KLF10 expression (62.5% vs. 51.3%, respectively; p = 0.005), and multivariate analyses showed that high KLF10 expression was the only independent factor correlated with greater overall patient survival. The significant correlation between high KLF10 expression and a higher 5-year survival rate was observed in certain subgroups of clinical parameters, including female gender, non-smokers, cancer stage T1, and cancer stage N0. Conclusions: KLF10 expression, detected by IHC staining, could be an independent prognostic marker for oral cancer patients.
Highlights
Introduction affiliationsOral cancer is the sixth most common cancer in the world [1,2]
Carcinogenesis and tumor progression are believed to be substantially linked to the dysregulation of cell proliferation and the apoptosis resulting from cell mutation [6]
Our study investigated tumor samples from patients with primary oral squamous cell carcinoma (OSCC)
Summary
Introduction affiliationsOral cancer is the sixth most common cancer in the world [1,2]. Krüppel-like-factor (KLF) family members are a group of transcriptional proteins containing three C2 H2 zinc finger DNA-binding domains with a Krüppel linker structure between the zinc fingers. These proteins are involved in cell proliferation and the activation of license We studied the impact of KLF10 expression on the clinical outcomes of oral cancer patients to identify its role as a prognostic factor in oral cancer. Materials and Methods: KLF10 immunoreactivity was analyzed by immunohistochemical (IHC) stain analysis in 286 cancer specimens from primary oral cancer patients. The 5-year survival rate was greater for patients with high KLF10 expression than for those with low KLF10 expression
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