Abstract
BackgroundGalectin-7, has a controversial role in tumor progression, can either suppress tumor growth or induce chemoresistance depends on different tumor histology types. The aim was to appraise Galectin-7 expression on the overall survival (OS) of patients with non-metastatic clear cell renal cell carcinoma (ccRCC) following surgery.ResultsHigh galectin-7 expression was specifically correlated with necrosis (P = 0.015). Multivariate analysis confirmed galectin-7 as an independent prognosticator for OS (P = 0.005). High galectin-7 expression suggested poor OS (P < 0.001), particularly with UISS intermediate and high score groups. Notably, the predictive accuracy of the traditional prognostic scores was improved when combined with galectin-7 expression.Materials and MethodsWe retrospectively enrolled 416 patients who underwent nephrectomy at a single institute between 2008 and 2009 and detected their intratumor galectin-7 expression by immunohistochemistry. Kaplan-Meier method was conducted to plot survival curves and multivariate cox regression analysis for potential independent prognostic factors on OS. A nomogram was constructed with concordance index (C-index) and Akaike's Information Criteria (AIC) to appraise prognostic accuracy of different models.ConclusionsHigh galectin-7 expression is an independent adverse predictor for survival. Evaluation of galectin-7 could help guide postsurgical management for non-metastatic ccRCC patients.
Highlights
Renal cell carcinoma, the most prevalent solid tumor of kidney malignancies, represents 2–3% of all human cancers [1]
High galectin-7 expression was correlated with necrosis (P = 0.015)
After applying initial exclusion criteria, the expressions of galectin-7 were assessed in an aggregate of 416 non-metastatic clear cell renal cell carcinoma (ccRCC) samples by immunohistochemistry staining analysis
Summary
The most prevalent solid tumor of kidney malignancies, represents 2–3% of all human cancers [1]. It’s reported that galectins expression changes in carcinoma cells under micro-environmental stress conditions during tumor development [8], thereby can be potentially novel prognosticators and targets [9]. M. et al and Labrie, M. et al reported galectin-7 was associated with cancer metastasis and chemo-resistant in breast and ovarian cancers, respectively [21, 22] All these important roles of galectin-7 in cancers of different histologic types had been identified, there haven’t any reports about the relationship between galetin-7 expression and RCC, whether it can promote or suppress tumor progression in RCC remained uncertain and its prognostic power in RCC needed to be declared. The aim was to appraise Galectin-7 expression on the overall survival (OS) of patients with non-metastatic clear cell renal cell carcinoma (ccRCC) following surgery
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