High expression of C-X-C chemokine receptor type 4 in the zona glomerulosa and in aldosterone producing adenoma

Abstract

Introduction: Chemokines are small secreted molecules that promote cell survival, proliferation and directional guidance of migrating cells in normal physiology and in tumour pathophysiology. We have recently observed high CXCR4 mRNA expression in both normal human adrenals and in adrenocortical carcinomas.