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Abstract
BackgroundAngiogenesis plays a critical role in tumor growth and metastasis. Angiogenic factor with G patch and FHA domains 1 (AGGF1) has been recently identified as a novel initiator of angiogenesis. However, the function and the prognostic values of AGGF1 in hepatocellular carcinoma remain poorly understood. Our aim is to provide more information to assist design the angiogenesis therapy that targets AGGF1 in HCC.ResultsAGGF1-positive frequency in HCC tissues was significantly higher than in peritumor tissues. The high expression of AGGF1 expression in HCC tissue was well associated with the increased expression of VEGF and the high microvessel density (MVD). AGGF1 expression predicts a poor prognosis and AGGF1 was an independent prognostic factor for DFS.MethodsThe expression levels of AGGF1, vascular endothelial growth factor (VEGF) and microvessel density (MVD) were identified by immunohistochemistry in 79 HCC tumor tissues and 24 corresponding peritumor tissues. The expression level of AGGF1 and MVD were quantified by counting the positively stained endothelial cells in the HCC and the peritumor tissue on the immunohistochemically stained tissue slides. The prognostic value of AGGF1 was evaluated by survival analysis.ConclusionsOur study shows that AGGF1 is identified as the independent prognostic factor for the disease-free survival (DFS) of patients after the surgical resection. contribute to tumor angiogenesis in HCC, which indicates that AGGF1 may be a new potential therapeutic target for anti-angiogenesis treatment for patients with HCC.
Highlights
Hepatocellular carcinoma (HCC) is the most frequent primary liver malignancy, which accounts for the 5th and the 3rd leading cause of death from cancer worldwide in women and men, respectively [1]
Our study shows that AGGF1 is identified as the independent prognostic factor for the disease-free survival (DFS) of patients after the surgical resection. contribute to tumor angiogenesis in HCC, which indicates that AGGF1 may be a new potential therapeutic target for anti-angiogenesis treatment for patients with HCC
HCC tumor tissues and 24 corresponding peritumor tissues, which were randomly selected from the 79 patients as control, were immunohistochemical analyzed to investigate the clinicopathological and prognostic roles of AGGF1 expression
Summary
Hepatocellular carcinoma (HCC) is the most frequent primary liver malignancy, which accounts for the 5th and the 3rd leading cause of death from cancer worldwide in women and men, respectively [1]. The development of cirrhosis is associated with high risk for developing HCC and the etiological factors are various, including hepatitis B virus (HBV), alcohol, other viral hepatitis such as hepatitis C virus (HCV), and nonalcoholic fatty liver disease (NAFLD) [2]. Angiogenic factor with G patch and FHA domains 1 (AGGF1) has been recently identified as a novel initiator of angiogenesis. The function and the prognostic values of AGGF1 in hepatocellular carcinoma remain poorly understood. Our aim is to provide more information to assist design the angiogenesis therapy that targets AGGF1 in HCC
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