Abstract
IntroductionThe fascin-1 protein is a cytoskeleton-like protein, which can prompt structural changes in cell membranes and affect the integrity of intercellular relations to promote invasion and metastasis of tumor cells. In this study, we researched the expression of fascin-1 in glioma.Material and methodsThe fascin-1 protein and mRNA were detected by immunohistochemistry and reverse transcription polymerase chain reaction (RT-PCR). Then, we analyzed the relationship between the expression of fascin-1 protein and the clinical pathological characteristics of patients with glioma. Finally, the fascin-1 protein expression status and prognosis of glioma patients were investigated.ResultsThe fascin-1 protein was mainly located in the cytoplasm of cells from glioma. The high expression rate of fascin-1 protein in glioma tissue was higher than that of normal brain tissue. At same time, we found that high fascin-1 protein expression was significantly correlated with World Health Organization (WHO) grading of glioma patients. The results survival analysis suggested high expression of fascin-1 protein in glioma patients with a shorter survival time. Multivariate analysis showed that high expression of fascin-1 protein was an independent predictor of the prognosis of patients with glioma.ConclusionsHigh expression of the fascin-1 protein indicates poor prognosis for glioma patients.
Highlights
The fascin-1 protein is a cytoskeleton-like protein, which can prompt structural changes in cell membranes and affect the integrity of intercellular relations to promote invasion and metastasis of tumor cells
We found that high fascin-1 protein expression was significantly correlated with World Health Organization (WHO) grading of glioma patients
According to the results of the immunohistochemical evaluation, fascin-1 was mainly located in the cytoplasm of cells obtained from glioma tissue (Figure 1)
Summary
The fascin-1 protein is a cytoskeleton-like protein, which can prompt structural changes in cell membranes and affect the integrity of intercellular relations to promote invasion and metastasis of tumor cells. We researched the expression of fascin-1 in glioma. Glioma is a gliacyte tumor originating from the brain neuroderm. It is the most common malignant tumor of the nervous system and accounts for about 45% of all intracranial tumors detected [1]. Characteristics of brain gliomas include high rates of morbidity, mortality, and recurrences. Chemoradiotherapy, and biotherapy are employed as interventions against glioma, recurrence of the tumor may occur in a short period. The current research focus includes a search for pathogenic factors of glioma that could be effectively translated into therapeutic targets for brain tumors. Grade I has the lowest degree of malignancy and patients have the best prognosis. Grade IV has the highest degree of malignancy and patients have the worst prognosis
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