Abstract
A single-step biomaterial-based microparticle fabrication procedure combining template synthesis, biomolecule assembly and partial-purification for high efficiency fabrication of pure biomaterial-based microparticles is reported.
Highlights
Paper (LbL) technique[19,20] or by additional chemical crosslinking processes and washing steps[21] for microparticle formation
Biomaterial-based microparticles were fabricated in a single step by a CaCO3 template-directed supramolecular coordination chemistry technique
The entrapped biomolecules simultaneously interact with the Ca2+ in the reaction medium during template formation, in which the biomolecules undergo self-assembly driven by Ca2+ coordination chemistry, resulting in construction of supramolecular structure within the CaCO3 template in a single step
Summary
(LbL) technique[19,20] or by additional chemical crosslinking processes and washing steps[21] for microparticle formation. These methods are tedious and time consuming, and usually require synthetic crosslinkers that may reduce compatibility and viability.[22,23,24] Research groups have previously reported the fabrication of organic– inorganic hybrid micro-structures by mixing CuSO4 and proteins without the use of crosslinkers.[25,26] The reported fabrication processes, though less laborious, require a considerable amount of time (at least 24 h) With these considerations in mind, we present in this paper a highly efficient single-step green approach for producing biomaterial-based microparticles by a CaCO3 templating technique. With minimal input of extra energy, harmful ingredients and pollution output, this fabrication process presents itself as a green protocol for the production of microparticles for biomedical applications
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