Abstract
Nanostructures have been lately identified as an efficient therapeutic strategy to modulate viral attachment and entry. The high concentrations of ligands present on nanostructures can considerably enhance affinities toward biological receptors. We demonstrate here the potential of carbon nanodots (C-dots) surface-functionalized with boronic acid or amine functions to interfere with the entry of herpes simplex virus type 1 (HSV-1). C-dots formed from 4-aminophenylboronic acid hydrochloride (4-AB/C-dots) using a modified hydrothermal carbonization are shown to prevent HSV-1 infection in the nanograms per milliliter concentration range (EC50 = 80 and 145 ng mL(-1) on Vero and A549 cells, respectively), whereas the corresponding C-dots formed from phenylboronic acid (B/C-dots) have no effects even at high concentrations. Some of the presented results also suggest that C-dots are specifically acting on the early stage of virus entry through an interaction with the virus and probably the cells at the same time.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.