Abstract
In this research, Graphene oxide (GO) used as a platform, is synthesized for the purpose of nanoparticles for loading of cyclophosphamide (CYP) and the identification of the structure of this new nano drug (CYP/GO) is made using several analytical devices such as XRD, FTIR, SEM, and UV. The morphology, functionalization, stability, loading and controlled release behaviors of cyclophosphamide on GO at different pH, temperatures, contact time and concentrations were investigated. The loading and controlled release of CYP indicated strong pH dependence which is implied hydrogen-bonding interaction between GO and CYP. The equilibrium adsorption data were analyzed by Langmuir and Freundlich models. The results showed that the adsorption behavior could be fitted better to the Freundlich model. Nearly 80 % of CYP was released in simulated gastric fluid, pH 1.2, in 4 h and 68 % in simulated intestinal fluid, pH 7.4, in 30 h.
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