Abstract
In this research, Graphene oxide (GO) used as a platform, is synthesized for the purpose of nanoparticles for loading of cyclophosphamide (CYP) and the identification of the structure of this new nano drug (CYP/GO) is made using several analytical devices such as XRD, FTIR, SEM, and UV. The morphology, functionalization, stability, loading and controlled release behaviors of cyclophosphamide on GO at different pH, temperatures, contact time and concentrations were investigated. The loading and controlled release of CYP indicated strong pH dependence which is implied hydrogen-bonding interaction between GO and CYP. The equilibrium adsorption data were analyzed by Langmuir and Freundlich models. The results showed that the adsorption behavior could be fitted better to the Freundlich model. Nearly 80 % of CYP was released in simulated gastric fluid, pH 1.2, in 4 h and 68 % in simulated intestinal fluid, pH 7.4, in 30 h.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callSimilar Papers
More From: Journal of Chemical Technology and Metallurgy
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
