Abstract
In summary, 60 minutes after beginning fibrinolytic therapy for acute myocardial infarction, significantly higher patency rates were observed after administration of 3.0 million U streptokinase as compared with 1.5 million U in a prospective, randomized, open trial (TIMI grade 2 and 3 in 52% vs 26%; p = 0.04). Thus, twice the conventional dose of streptokinase administered over 1 hour significantly improves very early coronary patency rates and should be studied further.
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