Abstract
Women undergoing radioiodine (RAI) therapy are advised to refrain from conceiving for 6-12 months following treatment as ovaries are exposed to radiation. It is unclear if this exposure carries a risk for reduced fertility, however earlier menopause has been reported in women undergoing RAI treatment. Given the finite number of primordial follicles women are endowed with at birth, radiation injury to germinal cells is not expected to be reversible. We sought to assess the effect of RAI on ovarian reserve of women undergoing treatment for differentiated thyroid cancer (DTC) by prospectively examining blood levels of anti-Müllerian hormone (AMH), and accepted index of the size of this reserve.
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