Abstract

Letters and Corrections1 February 1987High-Dose Overnight Dexamethasone Testing and Intercurrent IllnessROBERT P. CASTELLUCCI, M.D., JAMES K. SCHMITT, M.D.ROBERT P. CASTELLUCCI, M.D.Search for more papers by this author, JAMES K. SCHMITT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-2-332_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A recent report has noted that a high-dose (8 mg) overnight dexamethasone suppression test is helpful in separating patients with hypercortisolism due to Cushing's disease from those with adrenocortical tumors or ectopic adrenocorticotropic hormone secretion (1). It is well known that stress may result in serum Cortisol levels that are not suppressible by overnight testing with 1 mg of dexamethasone (2). The effect of high-dose overnight dexamethasone in stressed patients, however, has not been described.We recently saw a 65-year-old man who 1 month previously had had a right hemicolectomy and subsequent chemotherapy with fluorouracil for a...

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