Abstract
BackgroundVascular calcification (VC) is a risk factor for cardiovascular disease in end-stage renal disease (ESRD) patients undergoing maintenance haemodialysis (MHD). However, evidence is still insufficient about the association between dialysis parameters and VC. Thus, this study was to evaluate association of dialysis parameters with VC.MethodsWe enrolled 297 ESRD patients undergoing MHD at six distinct centers in Korea. Study participants were categorized into 3 groups by the scoring system of abdominal aortic calcification based on lateral lumbar radiography (no VC group: 0, mild VC group: 1–7 and advanced VC group: 8–24). We compared the features of dialysis parameters according to the severity of VC. Multivariate logistic regression analysis was used to calculate adjusted odd ratios (ORs) and 95% confidence interval (CI) for mild and advanced VC in each haemodialysis parameter (adjusted OR [95% CI]).ResultsPooled Kt/V (spKt/V), equilibrated Kt/V (eKt/V), standard Kt/V (stdKt/V) and the proportion of haemodiafiltration were increased along with the severity of VC. Multivariate regression analysis indicated that advanced VC was positively associated with spKt/V (5.27 [1.51–18.41]), eKt/V (6.16 [1.45–26.10]), stdKt/V (10.67 [1.74–65.52]) and haemodiafiltration (3.27 [1.74 to 6.16]).ConclusionHigh dose dialysis and haemodiafiltration were significantly associated with advanced VC.
Highlights
Vascular calcification (VC) is a risk factor for cardiovascular disease in end-stage renal disease (ESRD) patients undergoing maintenance haemodialysis (MHD)
ESRD patients that undergo haemodialysis have a 20–30-fold increased risk of cardiovascular mortality compared with an agematched population [2], which represents the majority of all-cause mortality in ESRD patients
While HD was more commonly used in the no VC group and mild VC group, HDF was more commonly used in the advanced VC group
Summary
Vascular calcification (VC) is a risk factor for cardiovascular disease in end-stage renal disease (ESRD) patients undergoing maintenance haemodialysis (MHD). Evidence is still insufficient about the association between dialysis parameters and VC. This study was to evaluate association of dialysis parameters with VC. ESRD patients that undergo haemodialysis have a 20–30-fold increased risk of cardiovascular mortality compared with an agematched population [2], which represents the majority of all-cause mortality in ESRD patients. Park et al BMC Nephrology (2020) 21:86 traditional cardiovascular risk factors like dyslipidaemia, hypertension, smoking, DM, obesity and advanced age contribute to pathological mechanisms of cardiovascular disease (CVD) in ESRD patients on haemodialysis [3]. Vascular calcification (VC) is highly prevalent in ESRD patients and is an independent predictor for cardiovascular (CV) morbidity and mortality.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
