High-dose biotin may down-regulate hepatic expression of acute phase reactants by mimicking the physiological role of nitric oxide

Abstract

There is recent evidence that nitric oxide blocks IL-6 signaling in hepatocytes by inhibiting activation of Stat3. If this effect is mediated by cGMP, then high-dose biotin – which can directly activate guanylyl cyclase – may have the potential to suppress hepatic production of acute phase proteins.