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Abstract
Multiple myeloma (MM) represents prototypical disease model to study tumor heterogeneity due to the high frequency of intra-clonal diversity within malignant clone of plasma cells (PC) in the bone marrow (BM). To better understand the myeloma heterogeneity within complex myeloma pathophysiology, we performed large-scale mass cytometry (CyTOF) analysis in the cohort of BM samples from MM patients (n=188) compared to 10 age-matched healthy donors (HD). We designed a pipeline for deep characterization of PC within the immune ecosystem of the myeloma microenvironment enrolling bone marrow of 16 MGUS, 25 smoldering MM (SMM), 43 newly diagnosed (NDMM) and relapsed or relapsed/refractory MM patients (n=104).
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