Abstract
Background:Urinary tract infections (UTIs) are common bacterial infections dominated by lower UTI in women (LUTIW). Symptoms only are insufficient for diagnosis and accordingly, near patient diagnostic tests confidently confirming significant bacteriuria are desirable. The nitrite test (NIT) has low sensitivity, while bacterial and leukocyte counts disjunctively paired in urine sediment microscopy (SED) have high sensitivity. Similar symptomatic cure rates are found post antibiotic vs. placebo therapy in patients with negative cultures. Consequently, prescription on symptoms only implies unnecessary antibiotic therapy.Aims:to evaluate the diagnostic outcomes of NIT, SED and NIT disjunctively paired with SED (NIT+SED) vs. urine culture, with special focus on bladder incubation time (BIT), and to assess if NIT+SED can reduce unnecessary antibiotic therapy.Methods:A diagnostic, primary care, multicentre study including 1070 women with symptoms suggestive of lower UTI.Results: Significant bacteriuria was found in 77%. The BIT highly influenced the diagnostic outcomes and the optimal duration was ≥4h with sensitivity of 66, 90 and 95% for NIT, SED and NIT+SED, respectively. SED performed only in NIT negative specimens could reduce unnecessary antibiotics by 10% vs. prescription on symptoms only. The number needed to test with SED to reduce one unnecessary antibiotic course was five patients at BIT ≥4h and six patients at ≤3h or overall.Conclusion:The BIT highly influences the diagnostic outcomes with the highest accuracy of NIT+SED. Diagnosis of LUTIW with NIT+SED can reduce unnecessary antibiotic therapy and subsequently decrease antimicrobial resistance. Trial registration:The Swedish Medical Product Agency 1995 03 01:151:01783/94.
Highlights
Urinary tract infections (UTIs) are common bacterial infections [1], estimated to 150 million episodes annually worldwide [2], dominated by uncomplicated, communityacquired, lower UTI in women (LUTIW) and often handled in primary care (PC) [3,4,5].Patients with LUTIW often want rapid relief of intensive symptoms [6]
The bladder incubation time (BIT) highly influences the diagnostic outcomes with the highest accuracy of nitrite test (NIT)+sediment microscopy (SED)
significant bacteriuria (SBU) was found in 77% of the included patients (827/1070), of which E. coli dominated in 81% (Table 1)
Summary
Urinary tract infections (UTIs) are common bacterial infections [1], estimated to 150 million episodes annually worldwide [2], dominated by uncomplicated, communityacquired, lower UTI in women (LUTIW) and often handled in primary care (PC) [3,4,5].Patients with LUTIW often want rapid relief of intensive symptoms [6]. Urinary tract infections (UTIs) are common bacterial infections [1], estimated to 150 million episodes annually worldwide [2], dominated by uncomplicated, communityacquired, lower UTI in women (LUTIW) and often handled in primary care (PC) [3,4,5]. The nitrite test (NIT) is the most commonly used near patient diagnostic test with varying diagnostic outcomes [1214], as 20-85% sensitivity in one meta-analysis [15] vs 3862% in another [16], which reported 73-100% specificity depending on different criteria for SBU. Urinary tract infections (UTIs) are common bacterial infections dominated by lower UTI in women (LUTIW). Symptoms only are insufficient for diagnosis and near patient diagnostic tests confidently confirming significant bacteriuria are desirable.
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