Abstract
288 High-density Mapping of the Human Sinus Node: The Effect of Atrial Remodelling Due to Atrial Flutter Martin Stiles ∗, Anthony Brooks, Bobby John, Dennis Lau, Hany Dimitri, Lauren Wilson, Christopher Wong, Pawel Kuklik, Glenn Young, Prashanthan Sanders Cardiovascular Research Centre, Royal Adelaide Hospital and the Disciplines of Medicine and Physiology, University of Adelaide, Adelaide, Australia Introduction: Sinus node function is impaired following atrial flutter (AFL). Detailed evaluation of the sinus node complex in normal and diseased atria may help understand sinus node function. Methods: Sixteen patients with chronic AFL and 15 agematched controls were studied following ablation. A 20-pole catheter positioned along the crista terminalis (CT) and a multi-electrode array were used for mapping. Features of sinus node function were determined during sinus rhythm and following pacing. Results: Both earliest activation (EA) and sinus breakout (SBO) points were further from the SVC-RA junction in patients with AFL (EA: 15± 12mm vs. 4± 5mm; SBO: 23± 11mm vs. 9± 6mm, p< 0.001). Following pacing, caudal excursion was less for patients with AFL. EA 3 (IQR−4 to 11) vs. 10 (0–19mm), p< 0.001; SBO 3 (0–6) vs. 7 (0–10mm), p= 0.03. Patients with AFL demonstrated g t C t e
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