Abstract
Sodium- and energy-dependent accumulation of [ 3H] l-glutamic acid (Glu) into rat cerebral cortical slices was inhibited by relatively high concentrations (40–100 μM) of calmodulin antagonists, such as N-(6-aminohexyl)-1-naphthalenesulfonamide and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, in concentration-dependent and noncompetitive manners. The latter antagonist not only diminished the basal binding activity of [ 3H]Glu in synaptic membranes of the rat brain, but also eliminated the activities found in the presence of Cl − and Cl −/Ca 2+ ions. However, N- methyl- d-aspartate-sensitive [ 3H]Glu binding was not affected by these antagonists. These results suggest the possible involvement of the calmodulin system in glutamatergic neurotransmission in the brain.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
