Abstract
Complexation and aggregation of DNA in small particles are the bases of efficient vehicles for gene delivery. The aggregation properties of new linear polycationic polynorbornene polymers with acetate counterions are described. These polymers spontaneously form stable latexes in water, offering a large cationic surface for favorable adsorption of DNA. Furthermore, such polymers are able to bind and efficiently compact the DNA into very small aggregates because of cationic charges and the hydrophobic packing of norbornane units. By use of transmission electron microscopy, atomic force microscopy, gel electrophoresis, and zeta potential measurements, we have studied both the polymer organization and the DNA−polymer complex formation.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.